Released on = October 16, 2006, 10:57 am

Press Release Author = Debra Thai

Industry = Biotech

Press Release Summary = The prefixing of "homo" to the name of an amino acid
indicates the addition of a methylene (CH2) group on the a-carbon of an amino
acid1,2. These are used for creating peptide analogs that have may have altered
biological activity.

Press Release Body = An example is shown in Shimizu's paper3 where certain amino
acids in the parathyroid hormone peptide PTH (1-14) have been substituted with Aib
(aminoisobutyric acid) and homoarginine. This shorter N-terminal fragment is found
to be as potent as PTH (1-34) for stimulating cAMP formation in PTH-1
receptor-expressing cells.

AnaSpec, a leading provider of integrated proteomics solutions, provides a source of
homo-amino acids suited for either drug discovery or investigation of peptide
biological activity.

Homo-Amino Acids:
· Fmoc-homoarginine(Pbf)-OH
· Fmoc-S-trityl-L-homocysteine
· Boc-S-trityl-L-homocysteine
· Fmoc-L-homophenylalanine
· Fmoc-D-homophenylalanine
· Fmoc-homoproline-OH or Fmoc-Pip-OH
For more information visit www.anaspec.com

References:
1. Internet. http://www.chem.qmul.ac.uk/iupac/AminoAcid/AA1n2.html#AA23/ Sept. 27,
2006.
2. IUPAC Commission on the Nomenclature of Organic Chemistry (CNOC). Nomenclature of
Organic Chemistry, Section F: Natural Products and Related Compounds,
Recommendations 1976, Eur. J. Biochem. 86, 1 (1978).
3. Shimizu, N. et al. J. Bone & Mineral Res. 19, 2078 (2004).



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